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The Health Zone Newsletter
Vol 02/2007

In this issue:
Stored Calories May Raise Cancer Risk
Herbalife Establishes a New Casa Herbalife Program in South Africa

Stored Calories May Raise Cancer Risk
By Daniel DeNoon WebMD, January 2007

It's not the calories you eat -- it's the calories you don't burn off that increase cancer risk, studies of mice suggest.

It's now well known that a restricted-calorie diet cuts the risk of getting cancer and slows the growth of some cancers. Most researchers think this is directly related to calorie intake. But not Tim Nagy, PhD, professor of nutrition sciences at the University of Alabama, Birmingham. When you eat more calories than you burn off, you store the extra calories as fat. Nagy wondered whether it's these extra fat cells, rather than the extra calories themselves, that affect cancer risk. To test this idea, Nagy's research team devised a clever experiment with mice genetically engineered to get prostate cancer.

They fed two groups of mice exactly the same number of calories. But one group of mice lived in cages warmed to a balmy 80.6 degrees Fahrenheit. The other group's cages were kept at 71.6 degrees. Mice in the cooler cages burned more calories to keep warm. After three weeks, they weighed less than the warmer mice. And they were less likely to have prostate cancer.

In a second experiment, both groups of mice were allowed to eat all they liked. The mice in the cooler cages ate about 30% more than the warmer mice. They wound up as fat as the warm mice. And they got prostate cancer at about the same rate -- despite their extra calories.

All in the Fat?
"This study suggests that ... being lean as opposed to being obese has a greater protective effect against cancer," Nagy says in a news release. "Excess calorie retention, rather than consumption, confers cancer risk."

Fat cells, Nagy and colleagues note, aren't just storage cells that hold extra energy. These cells emit many kinds of chemical signals that have profound effects on the body. One of these signals is called leptin. Leptin promotes some cancers. The heavier mice in the Nagy study had higher leptin levels than the cooler, leaner mice.

Another signal is adiponectin, which seems to protect from cancer. The fat cells of obese people don't give off as much adiponectin as fat cells of lean people. The heavier mice in the Nagy study had lower adiponectin levels than the cooler, leaner mice.

Exercise the Answer?
It's not a good idea for people to chill themselves in order to avoid cancer. But maybe, Nagy and colleagues suggest, people could get the same effect by exercising more. That, too, burns calories. "From a public health standpoint, it would be interesting to determine if a similar benefit [as that seen in the cooler mice] could be achieved with exercise," Nagy and colleagues suggest.

The study appears in the Jan. 1 issue of the journal Cancer Research.

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Herbalife Establishes a New Casa Herbalife Program in South Africa

The Herbalife Family Foundation (HFF) has established a new Casa Herbalife program at Acres of Love in South Africa, supporting children in need through good nutrition.

In 2005, HFF introduced Casa Herbalife, a program to help provide healthy and nutritious meals by partnering with existing charities serving children. This program for children-at-risk is named after Casa Herbalife, an orphanage the HFF built in Brazil in 1998 and continues to support today.

Acres of Love, in South Africa, was founded in 1998 to support orphans and abandoned children living with or affected by HIV and AIDS in and around Johannesburg. With 12 houses in the city, its aim is to provide 'forever' homes for each child, ensuring he or she receives the long-term care and assistance they need to develop physically and emotionally. Some, but not all of the children, may later be adopted. Good nutrition plays a key role for all of them.

Herbalife CEO Michael O. Johnson visited Acres of Love with Herbalife independent distributors who, along with their colleagues, will be supporting the programs on a local basis moving forward.

This new Casa Herbalife programs brings the total number established by the Herbalife Family Foundation worldwide to 17.

The Herbalife Family Foundation is a private, non-profit organisation supported by Herbalife Ltd., its independent distributors, employees, friends and families. Created in 1994 by Herbalife founder Mark Hughes, the Herbalife Family Foundation's mission is helping children in need by offering support in overcoming life's most basic challenges, from escaping poverty, hunger and abuse to receiving adequate medical care and education. In addition to developing Casa Herbalife programs worldwide, HFF often responds to natural disasters by establishing special funds, as it did for victims of the tsunamis, earthquake and hurricanes that struck in 2004 and 2005.

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